Sertraline: effects, dangers, when to take this psychotropic drug?

Sertraline is a psychotropic drug indicated, among other things, for major depressive episodes (or to prevent depressive recurrence) or certain forms of anxiety. What indications? What dosage? Which side effects? Does sertraline make you sleep? Point.

Definition: What is sertraline?

Sertraline is a Psychotropic drugs used as antidepressants. Due to its mode of action, this molecule belongs to the group of selective serotonin reuptake inhibitors (SSRIs). Sertraline was discovered and brought to market early 90s from the Pfizer lab.

How does sertraline work?

Sertraline is a antidepressant belongs to the SSRIs, strong and selective serotonin reuptake inhibitors (5-HT serotonin). That serotonin is a Neurotransmitter that is naturally secreted by the body which intervenes at various levels, such as B. in the central nervous system, in the digestive system, in hemostasis and in the regulation of the circadian cycle. More specifically, serotonin helps regulate the mood and are associated with feelings of happiness and reducing risk-taking (unlike dopamine). Depression or anxiety can be explained by a reduced serotonin level in those affected. By preventing the reuptake of serotonin, Sertraline then helps increase levels of this neurotransmitter at the level of the neurons present in the brain that induce the therapeutic effects of serotonin, including an improvement in mood and Reducing anxiety, phobias, stress and panic disorders. Its selective action on the reuptake of serotonin, without particular affinity for muscarinic (cholinergic) receptors, GABA, adrenaline (and noradrenaline), dopamine and histamine, allows no (or very little) stimulating, hypotensive or depressant action on the central nervous system.

Indications: when to take sertraline?

Sertraline is indicated in severe depressive episodes (or to prevent depression from recurring) of certain forms fear (e.g. post-traumatic stress disorder or social phobia), obsessive compulsive disorder in adults and children over 6 years of age or panic attacks. It is a listed drug that requires a medical prescription to be delivered. Only the prescribing doctor has the authority to determine in which cases this treatment is justified, as well as to determine the dosage and duration of the treatment.

What medicines contain sertraline?

Sertraline is included in the commercial specialty Zoloft® as well as in generics under the name of sertraline, distributed by various laboratories. These drugs come in the form of 25 or 50 mg tablets or capsules to swallow.

How long does sertraline work?

Like all antidepressants, sertraline generally requires up to 2 to 4 weeks before the beneficial effects become visible. Although the therapeutic effects can set in after a few days of treatment, its optimal efficiency unavailable for several weeks.

What Are the Side Effects and Dangers of Sertraline?

The side effects of sertraline can be numerous but generally occur more frequently in the first few weeks of treatment and generally subside thereafter. Are frequently observed Nausea, sexual problems, loss of appetite, drowsiness or on the contrary insomniaabnormal dreams or nightmaresof dizzinessof tremors, headachea Declining attentiona blurred visionof ringing in earsof yawnsof Vomitof constipationof Diarrheaof stomach painof drought Mouth and taste change, a sweat exaggerated, whoops from heat, respiratory infections superiors, rashes, of fatiguea catch of weightof Pains muscles or joints. Less commonly, confusion, hallucinations, anxiety, suicidal thoughts, convulsions, involuntary movements, difficulty urinating or, on the contrary, urinary incontinence, dilation of the pupils, change in blood pressure, loss of milk, priapism, allergic reaction. Serotonin reuptake inhibitors, antidepressants (known as SSRIs) can also cause it Restlessness and uncontrollable need to move, bleeding (bruising, nosebleeds, genital or digestive bleeding) and less commonly a Serotonin Syndrome (SS) Where Neuroleptic Malignant Syndrome (NMS)) which can be serious or even fatal, causing tremors, confusion, restlessness, muscle stiffness, dizziness, fever and sweating. Sometimes a syndrome weaning may be seen with the onset of certain symptoms (anxiety, guilt, nightmares, tremors, dizziness) that require gradual withdrawal of sertraline over a period of at least one to two weeks. Sertraline is like all antidepressants not recommended for children and adolescents for the latter, suffering from depression, is likely to increase the risk of suicide. Its use in children under 18 years of age must therefore be reserved for certain serious cases and under strict supervision (medical and by their environment). Psychotic symptoms can be exacerbated in people with schizophrenia.

Does sertraline make you sleep?

Relatively common side effects of sertraline include sleepiness can be observed when taking this drug, although this effect is not systematic, since sertraline can also cause it and vice versa insomnia.
Due to the positive therapeutic effect of serotonin on mood, stress, anxiety and panic attacks, sertraline can help improve sleep.

What are the contraindications for sertraline?

Grapefruit can increase side effects

Sertraline should not be used in this case allergy against sertraline or an excipient contained in the drug or in combination with Monoamine Oxidase Inhibitor Drugs (MAOIs) even if taken within the last two weeks (due to the risk of serotonin syndrome) and medicines containing pimozide (due to the risk of heart disease). In addition, sertraline not recommended for children and adolescents have depression before the age of 18, as this may increase the risk of suicide. It is reserved for adolescents in certain severe cases, under increased medical and family supervision. In the event of manic episode which lead to euphoria, excitement or behavioral problems, emergency medical advice is required. It is also advisable to be vigilant in case of a history epilepsyfrom glaucoma closed angle, bleedingfrom heart disease and from diabetes. In fact, people with diabetes may need to adjust the dose of the medication because taking sertraline at the same time is likely to alter blood sugar. Sertraline can interact with some migraine medications (triptans), others antidepressants, medicines based on tramadol, fentanyl, buprenorphine, methadone, lithium or St. John’s wort as this could lead to serotonin syndrome. Caution is also advised with concomitant use of an oral anticoagulant, aspirin, anti-inflammatory drug (NSAID), antiarrhythmic, imipramine antidepressant, neuroleptic, diuretic, or drug containing orlistat. TakeAlcohol is not recommended during treatment with sertraline. The consumption of Grapefruit (including juice) may also increase the side effects of sertraline. Caution is advised when taking sertraline in people with liver failure.

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