DNA Script enables q/dPCR assay development in one day, from design to results, with next-generation SYNTAX kits being launched at AGBT

  • The new generation SYNTAX kits now allow the synthesis of probes labeled with fluorophores, quenchers or biotin.

  • It’s the fastest solution for custom q/dPCR testing and, for the first time, delivers same-day results at the best price on the market.

  • In addition to PCR, these new kits can also be used for NGS, ISH and FISH analysis

SOUTH SAN FRANCISCO, California and PARIS, June 6, 2022–(BUSINESS WIRE)–At the conference today Advances in genomic biology and technology (AGBT), DNA Script, the world leader in enzymatic DNA synthesis (EDS) for on-demand DNA, announced the launch of the first solution enabling same-day personalized q/dPCR testing, thanks to a new generation of Kits for the SYNTAX system that allows printing primers and probes in a few hours. This announcement comes two days before the AGBT presentation on Wednesday, June 8 at 2:55 pm EST, during which the founders will present updated data illustrating new applications and the performance of the SYNTAX system.

For the first time since the introduction of PCR in 1984, labs can design and print q/dPCR tests right in the field and on their lab bench in as little as 8 hours. Increased performance, combined with setup in as little as 15 minutes, fast turnaround time, and complete workflow control, offers labs the best value for money for custom-modified DNA fragments. The new kits are designed to accelerate genomic assay development workflows, particularly for q/dPCR, NGS, ISH and FISH assays.

“The launch of this product is a real paradigm shift. It enables our customers, SYNTAX users, to design and implement custom tests in less than a day, even before others speed, whether it’s an upcoming scientific publication, a new diagnostic test, or even a vaccine“said DNA Script CEO and co-founder Thomas Ybert, Ph.D. “With an on-site SYNTAX benchtop system and these new kits, we enable our customers to replace a complex synthesis process with a single instrument, dramatically reducing iterative assay development from months to days.”

This latest kit generation brings new features to the SYNTAX platform:

  • Print longer DNA fragments up to 80 nt in length

  • Synthesize q/dPCR primers and probes in as little as 8 hours.

  • Print DNA fragments with higher yield and concentration (≥7 µM and ≥600 pmol).

  • Label the probes with fluorophores, quenchers, or biotin.

DNA Script’s SYNTAX platform offers researchers significant time savings by printing primers and probes in 8-12 hours and offers the best value per assay compared to leading DNA fragment solutions on the market. Early adopters of the SYNTAX platform have already leveraged on-demand synthesis to remove bottlenecks in the development of biothreat detection assays, rapid response assays to viral outbreaks, and new vaccines and therapies.

The SYNTAX system is a game changer for preclinical research organizations (CROs) like ours. For the biomarker identification and gene expression profiling we do, we spend thousands of dollars a month on primers and probes just to wait for them to be synthesized and shipped. SYNTAX’s on-site presence shortens our assay turnaround times, lowers their unit costs by approximately 30%, and allows our lab to optimize expression assays more quickly, significantly improving our results.“said Jonathan Wray, managing partner at DC3 Therapeutics.”DNA Script’s ease of use and excellent customer service got us up and running with the SYNTAX system in no time..”

As a Bronze Sponsor for the duration of the AGBT conference, DNA Script has provided a presentation lounge in the Jade Lexington suite where attendees can see the SYNTAX system in action, its speed of probe synthesis and primers with plug and play Simplicity and automation. Individual demonstrations can be arranged in advance.

DNA Script presentations at AGBT include:

● Panel presentation: Same-day enzymatic DNA synthesis: print labeled primers and probes with the SYNTAX system now.
Speakers: Thomas Ybert and Xavier Godron, Technical Director and co-founder of DNA Script, Doctor of Medicine.
Date and Time: Wednesday, June 8, 2:55 PM – 3:15 PM EDT
Venue: Main Session – Florida AL Salons

● Poster presentation (#517): Enzymatic DNA synthesis (EDS) provides rapid access to synthetic oligos for the production of expression vectors for SARS-CoV-2 spike variants.
Presenters: Benoit Derrien, Ph.D., Application Project Manager, DNA Script
Date and Time: Tuesday, June 7, 1:30 p.m. – 3:00 p.m. EDT
Venue: Bonnet Creek Ballroom Salon VII-XII

● Poster presentation (#540): Access to synthetic oligos produced by enzymatic DNA synthesis (EDS) accelerated the development of Candida glabrata mutants during the COVID-19 pandemic.
Speakers: Colin Clairet, Ph.D., Postdoctoral Fellow, Institut Pasteur
Date and Time: Wednesday, June 8, 4:40 p.m. – 6:10 p.m. EDT
Venue: Bonnet Creek Ballroom Salon VII-XII

“Since providing the world’s first commercial access to enzymatic DNA synthesis via the SYNTAX platform in the summer of 2021, we have made a number of improvements to advance on-site and on-site DNA printing. benchsaid Thomas Ybert. “Given the many applications and the urgent need to realize them quickly, on-site DNA printing-on-demand is emerging as one of the most important technologies of the 21st century.”

About DNA script

Founded in 2014, DNA Script is a pioneering life science technology company developing a new, faster, more powerful, and more versatile way to design and manufacture DNA. The company has developed an alternative to traditional DNA synthesis called enzymatic DNA synthesis, or EDS, and brought this technology to laboratories with the first benchtop instrument for enzyme synthesis, the SYNTAX system. By bringing DNA synthesis back to the lab, DNA Script aims to transform life sciences research with innovative technology that gives researchers unprecedented control and autonomy.

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