Plus d'un million de Français sont touchés par la maladie d'Alzheimer qui est le résultat d'une lente dégénérescence des neurones entrainant des troubles de la mémoire récente, des fonctions exécutives et de l’orientation dans le temps et l’espace. © Artur, Adobe Stock

Alzheimer’s: Blood transfusions slow the progression of the disease

Although we don’t know how to treat Alzheimer’s disease, researchers have tested a new method to slow its progression: blood transfusions. According to them, they would prevent the aggregation of beta-amyloid peptides, which are partly responsible for the damage caused in the brain.

main form of dementia in the world, the Alzheimer’s disease is a neurodegenerative diseasefor which there is no cure. Caused by accumulation of abnormal protein aggregates in brain function
The brain is located in the cranial box and is the seat of higher (cognitive functions, senses, nerve reactions) and vegetative functions. It is therefore an essential organ that regulates everything…” data-image=” .jpg” data – url=”” data-more=”Read more”>Brain, it develops slowly over years, but always leads to the death of the affected person. More specifically, these are the tau proteins and amyloid peptides beta Who’s to blame: Beta amyloids build up and form amyloid plaques on the outside of neuron structures
Each neuron consists of:
a cell body or perikaryon containing the nucleus; very many dendritic branches (therefore …” data-image=” /8/4/4845b46c32_50034180_neuron -dr.jpg” data-url=”” data-more=”Read more”>neurons and then block the interneuronal communication. For their part, the tau proteins are found deformed, tangled and in large quantities at the level of the destroyed neurons.

There are around 50 million cases worldwide and almost a million in France, with the majority of people being over 65 years old. Very often the disease is recognized too late. As the first symptoms occur, such as memory loss, speech disorders, mood disorders or disorientation… the brain is already damaged. Although there is no specific treatment to stop or even slow down the disease, researchers have investigated a way to prevent the aggregation of Beta Amyloid Proteins and their cerebral deposition. Her technique, detailed in a publication of the journal Nature – Molecular Psychiatryis based on a blood exchange, i.e. a large number of blood transfusions.

Decreased amyloid plaque development in mice by 40-80%

Currently, the treatments tested do not work, according to the researchers, mainly for one reason: the so-called simple covalent bond…” data-image=” midioriginal/d/ 0/e/d0e3dc7e1e_76472_molecule.jpg” data-url=”” data-more=”Read more”>molecules Treatments are stopped by the blood-brain barrier, which isolates the brain from the bloodstream and acts as a filter. Rather than trying to eliminate amyloid plaques already present in the brain, the researchers focused on prevention, which is based on avoiding negative disorders or reducing their…” data-image=” https://cdn.futura-sciences .com/buildsv6 /images/midioriginal/0/7/0/070bdc60f3_50035320_amenagement-prevention-crue-clive-perrin-geograph-cc-2.jpg” data-url=” definitions/developpement-Durable-Prevention-6509/” data-more=”Read more”>prevention Aggregation of peptides into plaques. Their idea: to supply diseased mice with “new” blood and observe the development of amyloid plaques.

Their idea: to supply diseased mice with “new” blood and observe the development of amyloid plaques

“Blood vessels in the brain are traditionally considered the most impermeable barrier in the body.said Akihiko Urayama, first author of the study and researcher Mitchell Center for Alzheimer’s Disease in Houston. We realized that the barrier is also a very specialized interface between the brain and the systemic circulation.”

They injected sick mice “normal blood from wild-type mice with the same baggage genetically », while they take it from them to do a real blood exchange. After numerous blood transfusions, in addition to an improvement in performance, they noticed a 40-80% reduction in the development of amyloid plaques and a decrease in their growth rate over time spatial memory in older mice.

as they explain “The exact mechanism by which blood exchange reduces amyloid pathology and improves memory is currently unknown.” However, they assume that a decrease in beta amyloids in the blood would then redistribute those contained in the brain into the blood. After all, according to the researchers, this marks a new hope in the treatments.

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