Un implant expérimental de tissu vivant bio-imprimé en 3D a été greffé sur une patiente atteinte de microtie, une maladie congénitale qui se caractérise par une oreille externe incomplète. © Ciseren, Getty Images

An ear from the lab successfully transplanted!

In the United States, a 20-year-old woman suffers from a malformation of theEar received one graft Designed from human cells and a 3D printer. This world first helps people with microtia, a anomaly congenital structure of the outer ear
The outer ear is both a protective and resonant structure; it includes the pavilion (or pinna) and the ear canal, which culminates in the…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/4/7/f/ 47f7a6ef4f_50036304_ear -drjpg.jpg” data-url=”https://news.google.com/health/definitions/medicine-external-ear-8573/” data-more=”Read more”>auricle. In the future, this technology could be extended to other therapeutic areas.

On June 2nd, the team led by Arturo Bonilla, founder and director of Microtia-Congenital Ear Deformity Institute in the United States, performed a transplant ofimplant of a human ear created from a 3D printer. This implant, called AuriNovo, was developed by 3DBio Therapeutics, a biotechnology specializing in regenerative medicine.

This implant was developed to provide an alternative for people with microtia, “a rare congenital malformation in which one or both outer ears are missing or underdeveloped”. the company in a press release. In Europe, this anomaly would affect 15 out of approximately 100,000 births.

To create the prosthesis of the 20-year-old patient, the specialists took the patient’s cartilage cells, cultivated them in the laboratory and mixed them with themhydro gel from collagen. then you have 3D printed the result in the form of the “healthy” ear.

The implant consists of the patient’s cartilage cells

This surgery could become a less invasive alternative to the surgery usually offered to people with microtia. ” I hope that one day AuriNovo will become the standard of care, replacing current surgical methods of ear reconstruction that require removal cartilage costal or the use of implants, depending on the polymerisation process, polyethylenes can be classified as “low density” (LDPE), “high density” (HDPE),…” data-url=”https://news.google .com/sciences/definitions /chemistry-polyethylene-2889/” data-more=”Read more”>polyethylene porous (PPE) “, explains Arturo Bonilla.

With this technological progressthe ear should follow the growth and development of the transplanted person, as the founder of the Microtia-Congenital Ear Deformity Institute. ” We also expect that this will result in a more flexible ear than reconstruction with an EPI implant. “.

This operation was performed as part of a clinical trial which takes place over five years in two US states, California and Texas. A total of eleven people aged 6 to 25 with microtia will receive an implant.

This clinical trial could also allow for an extension new technology to other therapeutic areas. ” Our first indications are focused on cartilage in the areas of reconstruction and The orthopedist takes care of many problems: fractures, osteoarthritis, bone and joint infections, scoliosis, polydactyly,…” data-image=” https://cdn. futura-sciences.com/buildsv6/images/midioriginal/b/8/3/b836950dbe_46407_polydactilie.jpg” data-url=”https://news.google.com/sante/definitions/medecine-orthopedie -13996/” data- more=”Read more”>orthopedicsincluding the treatment of complex nasal malformations and spinal degeneration said Daniel Cohen, Founder and CEO of 3DBio Therapeutics.

A 3D printed biocompatible human ear

Thanks to a form of 3d printing and a gel is a semi-solid liquid.” data-url=”https://news.google.com/planete/definitions/geologie-gel-1496/” data-more=”Read the definition”>freeze Scientists have succeeded in creating an artificial, functional and biocompatible human ear from collagen and living cells that could be used for people with deformities. Within months, the cells replace the collagen with real cartilage.

Article by Janlou Chaput, published February 25, 2013

That surgery Restorative could enter a new era: that of3d printing. Usually specialists use products that are similar texture of the injured organ or harvesting tissue from other parts of the body. This is usually taken care of ears.

Patients who have lost their pinna due to an accident, cancer, or a birth defect called microtia are given either a prosthesis from building materials, intelligent materials, ecological materials…
A…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/6/4/8/648b91afa7_92816_material.jpg” data-url=”https://news.google .com/sciences/definitions/physics-material-15914/” data-more=”Read more”>material They don’t have roots, they have structures called…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/a/9/b /a9b9211bba_50035047_bryophyte-sporophyte-sporangium-theotherjohnc-cc .jpg” data-url=”https://news.google.com/planet/definitions/botany-bryophyte-5908/” data-more=”Read more”>mousse from polystyreneor have part of it cartilage of their ribs, with which the surgeon forms the pavilion. Often this last strategy proves not only painful, but also without real success.

But those times could be over in a few years, thanks to researchers from theCornell University (New York). In the open access journal Plus oneexplain how they managed to create a biocompatible artificial ear using modern tools.

A 3D printer, some gel and you get an ear

The first step is to create a three-dimensional image of the ear to be shaped. Thanks a 3D printer, the photo becomes a hollow shape with the shape of the pavilion and the mace. A gel is injected into it, which consists of collagen mixed with ear cells Cow. After The reverse phase change is called “melting”. Solidification is to be distinguished from evaporation, which allows the passage of…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/b/4/f/b4f77ade23_82084_solidification.jpg ” data-url=”https://news.google.com/sciences/definitions/physics-solidification-15303/” data-more=”Read more”>solidificationthe prosthesis is placed in the nutrient medium to nourish it cells so that they can form cartilage. After a few days, the ear is ready to be inserted.

To verify the biocompatibility and viability of their structure, the authors implanted the artificial ears on the The purpose may be to compromise an online service or a company’s network by…” data-image=”https: //cdn .futura-sciences .com/buildsv6/images/midioriginal/e/f/f/eff315adf5_103383_deni-service-dos-ddos.jpg” data-url=”https://news.google.com/tech/definitions /internet- deni-service- 2433/” data-more=”Read more”>the back of rats. That graft accepted well and after three months the prosthesis had become cartilaginous like the natural organ. Proof that the device can exist in a living organism.

Artificial ears available in a few years

From design to installation, such a process takes only a few days to be implemented. The authors estimate the time required for procurement to be half a day photo of the ear. 3D printing takes about 24 hours. The injection of the gel takes 30 minutes and its solidification only 15 minutes. Add a few days of cultivation and you’re done.

Scientists now hope to be able to work with human ear cells, and particularly cells from a patient, to limit the risks transplant rejection inherent in any living tissue implantation.

For patients with microtia, the researchers point out that the best age to have reconstructive surgery is around 5 or 6 years old. At this age, the ear is typically 80% of its adult size. The first human trials are expected in three years. When the test requests are answered…

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