Can Exercise Really Help Fight Parkinson’s Disease? At least that’s what the study published in the journal on July 31 Proceedings of the National Academy of Sciences (PNA) on Aug. 31. According to the work of researchers at Johns Hopkins Medicine and the Dana Farber Cancer Institute in Boston, USA, a Hormone released into the blood during endurance sports or aerobic exercise would lower levels of a protein linked to Parkinson’s disease and halt movement problems in mice.
With the knowledge that Parkinson’s disease is a neurological condition that results in loss of muscle and movement control, this important discovery is on the wane to get an insight into the pathway of a possible treatment of Parkinson’s disease based on this sport hormone called “Irisin”. This also confirms the importance of physical activity for people with Parkinson’s disease to reduce their symptoms and improve their mobility.
No movement deficit thanks to irisin protein
Without really knowing the reasons, we’ve known for a long time that the Endurance exercise reduces the symptoms of Parkinson’s disease. Ted Dawson of Johns Hopkins Medicine and Bruce Spiegelman of the Dana Farber Cancer Institute therefore collaborated in this study to investigate the link between irisin, an exercise molecule produced during exercise, and Parkinson’s disease. You should know that first When alpha-synuclein proteins clump together, these clumps kill brain cells Production of dopamine, an important trigger of Parkinson’s disease. According to Professor Ted Dawson, the author of the study, the fibrous clumps of alpha-synuclein are very similar to those found in the brains of people with Parkinson’s disease.
To the to investigate the influence of the exercise hormone irisin on Parkinson’s disease, the researchers tested the effects of irisin on mice that had been previously modified to show symptoms similar to those of Parkinson’s disease. In practice, as reported by the site science dailyThe scientists injected alpha-synuclein into an area of the mouse brain called the striatum, where dopamine-producing neurons line up.
Two weeks later, the researchers injected the mice with a viral vector that increased blood levels of irisin, which can cross the blood-brain barrier. As a result, six months later, the Mice received irisinthe hormone produced during exercise showed none no deficit in muscle movementwhile those injected with a placebo showed deficits in grip strength and the ability to descend a pole.
Parkinson’s: Alpha-synuclein levels reduced by 50 to 80%
Further studies on the brain cells of mice given irisin also showed this Exercise hormone reduced alpha-synuclein levels associated with Parkinson’s disease by 50-80%. The research team showed that irisin also speeds up the transport and breakdown of alpha-synuclein across fluid-filled sacs called lysosomes in brain cells.
“If the usefulness of irisin is proven, we could consider making it into a recombinant gene or proteinsaid Ted Dawson, referring to drug development aimed at using cellular genetics to treat disease. The study’s co-author is the Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases, Professor of Neurology and Director of the Johns Hopkins Institute for cell engineering.
Parkinson’s disease: Irisin, a possible treatment?
“Given that irisin is a naturally produced peptide hormone and appears to have evolved to cross the blood-brain barrier, we think it’s worth it continue to evaluate irisin as a potential therapy for Parkinson’s disease and other forms of neurodegeneration,” concluded study co-director Bruce Spiegelman reinforces the value of exercise for patients with Parkinson’s disease to relieve their symptoms and maintain better mobility.
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